Although our analyses clearly demonstrate that purifying selection acts on intron splice sequences, it is less clear what specifically is deleterious about perturbing intron splicing in yeast.
Alternatively, HOXD-encoded proteins or ncRNAs generated from the 3′ half of the cluster might be deleterious specifically to myogenic progenitor cells.
This also indicates that there is a synthetic lethal effect; the effect of targeting one gene (e.g. EZH2) becomes deleterious specifically in the absence of another gene (e.g. BRCA1) [ 34].
According to the systematic review by the Cochrane Collaboration, related vitamin D compounds used do not seem to have advantages when compared to vitamin D, and calcitriol, specifically, may be deleterious through an increase of documented adverse events.
Specifically, if most mutations deleterious in the mutagenic environment are also deleterious in a surrogate environment, the fitness decay over a few generations of mutagenesis may parallel each other in the two environments.
Specifically, we assume that deleterious mutations arise at the time of transmission and that they are removed from the population with recovery events of infected individuals.
Indrambarya and colleagues therefore elegantly demonstrate that cardiac ischaemia and subsequent reperfusion injury may specifically contribute to the deleterious side effects of AVP.
In our models, we include deleterious mutations, specifically hypomorphic mutations, to determine the relative importance of gene dose halving per se versus the effect caused by unmasking deleterious alleles.
More specifically, although fever is deleterious in the short and medium term in brain-injured patients, fever control, whether by hypo- or normothermia, allows reduction of the intracranial pressure at the expense of increased susceptibility to infections.
Thus, consistently across eukaryotes different versions of the CYSTM module appears to have a role in stress response or tolerance, and more specifically in resistance to deleterious substances, implying that this might be a general function of the superfamily.
Specifically, TIC Genetics searches for likely deleterious mutations that are shared by affected individuals within multiply affected families.
