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The 26S proteasome is the proteolytic unit of the ubiquitin-proteasome system and specifically degrades polyubiquitinated proteins.
Chemo-radiotherapy specifically degrades muscle mass, and depresses the function of mitochondria, the tiny structures that act as the boiler room of the cell, generating energy.
This study tested whether heparanase-1 (HPR1), an endoglycosidase that specifically degrades the heparan sulfate (HS) proteoglycans in the breast extracellular matrix, was associated with the most aggressive DCIS subtypes.
Conclusion: Since PAPP-A is a protease that specifically degrades insulin-like growth factor binding proteins we would conclude that the control of the insulin-like growth factor system in the first trimester of pregnancy might play a key role in determining subsequent pregnancy outcome.
The identities of dissected tissues were confirmed by qRT-PCR using primers for tissue-specific mRNAs for oleosin, 16 kDa isoform R16 (NCBI: AF022148), a structural protein found in oil bodies involved with lipid accumulation, and starch debranching enzyme (SDBE, Nakamura et al. 1996; NCBI: D50602), which specifically degrades amylopectin (Table 1).
As antioxidant, we used catalase which specifically degrades H2O2 into H2O.
Similar(21)
Presumably the uncapped 5′-ends in degradome datasets are a mixture of the randomly and specifically degraded products of various degradation pathways.
We used the GAL4/UAS ectopic expression system to drive tissue-specific production of a pkn double-stranded RNA that would specifically degrade pkn messenger RNA by RNA interference.
Therefore, GM plants exposed to glyphosate-based herbicides such as Roundup do not specifically degrade glyphosate.
Phospholipase A2 (PLA2) is highly expressed in tumor tissues to specifically degrade the 2-acyl of phospholipid to lysophospholipid.
MGMT protein was also specifically degraded in extracts from S-phase cells and evidence strongly suggested the involvement of PCNA-dependent CRL4Cdt2 ubiquitin-ligase in the reaction.
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