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This region-specific phenotype is particularly interesting as it is the midbrain neurons, which are specifically affected in PD, linking the mitochondrial phenotype to the parkinsonian behavioural phenotype observed in these mice.
It is also difficult to conclude that motion perception is specifically affected in glaucoma because most of these studies do not yield a comparison with other visual functions.
The first two have been shown to be task-sensitive and specifically affected in patients with neurological diseases such as epilepsy and movement disorders.
Three patients with atypical syndrome of nonfluent primary progressive aphasia (Mesulam's syndrome) were trained daily with a remediation protocol including auditory exercises specifically designed to involve several aspects of phonological processing, a domain known to be specifically affected in this condition.
Pretreating plants with benzothiadiazole (BTH, a chemical inducer of systemic acquired resistance) 2 days prior to Pseudomonas inoculation prevented bacterial growth in both wild type and rlk902 (Figure 2h).These data suggest that rlk902 is specifically affected in interactions with the obligate biotroph H.arabidopsidis.
Hence, in contrast to a previous study in Drosophila, which showed that memory scores shortly after conditioning were not influenced by aging, but LTM was, [13], our data does not lend support for retention of consolidated memory being specifically affected in old honey bees.
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Together, these observations could suggest that the worm can do with a minimal set of NHEJ factors consisting only of three core proteins (CKU-70, CKU-80, and LIG-4); however, a saturated and unbiased screen for factors specifically affecting in vivo NHEJ activity has yet to be performed.
In contrast, knockdown or inhibition of MCAK specifically affected turnover in pole-to-kinetochore microtubules without an apparent effect on spindle microtubules more generally [45]; [45].
We uncover duplications and accelerated evolution that specifically affected genes in the lineage preceding the group containing N. delphensis and the three pathogens, which may provide clues to the higher propensity of this group to infect humans.
Thus, the resultant tumor characteristics are probably determined by a combination of the phenomenon of gene downregulation per se and the properties of the specifically affected genes (in this case by STAT5ca).
Thin collagen fibres, termed microtendons, are also observed at myotendinous junctions [23], structures specifically affected by myopathy in COMP T585M mutant mice [24].
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