Large scale virtual screening methods have been an attractive approach for prescreening millions of compounds in commercial or public chemical databases to find compounds specifically active against a specific target, especially in early stages of modern drug development pipelines.
In contrast, α-kappa-ETA′, a similarly designed human kappa light chain-specific fusion protein, was only specifically active in combination with antibodies containing a human kappa light chain.
They found that ventrolateral prefrontal cortex (VLPFC) was specifically active during the attentional shift, whereas DLPFC activity reflected more the strategic and working memory demands involved in the EDS problem solution.
In order to identify candidate cholinergic neurons in the fly visual system we recently established an anatomical map [33] by employing the promoter for Cha which is specifically active in cholinergic neurons and by restricting its activity to single or few cells by mosaic analysis with repressible cell marker (MARCM).
Among them, a spermidine derivative (compound 13) was specifically active in vitro against Leishmania donovani axenic amastigotes (IC50 at 5.4 μM; Selectivity Index >18.5) and a spermine derivative (compound 28) specifically active against Trypanosoma brucei gambiense (IC50 at 1.9 μM; Selectivity Index >52).
Specifically, active control of the solid settling basin outlet improved solids retention and allowed the producers to match effluent application rates to the infiltration rate of the vegetative treatment area, reducing the occurrence of effluent release.
Concerns over the scalability of TCP's end-to-end approach to congestion control and its AIMD congestion adaptation have led to proposals for router-based congestion control, specifically, active queue management (AQM).
The management of tile-drained agricultural land to reduce NO3-N losses should focus explicitly on flow events and, more specifically, active management should preferably be conducted in the winter season for discharge events after snowmelt, after heavy rain storms and when the soil moisture conditions are wet.
CryptoMove– Developing cybersecurity solutions, specifically active defense data protection.
The initial four chemicals, VCRF, start by changing physical traits, acting on a gene called Tuj1, which is specifically active in neurons.
Mike Isaac at AllThingsD also points out that while the 90 million figure being reported today may look weak compared to the 100 million users it reported last September, these are specifically active accounts, where previously the company only shared data on straightforward registrations, which means total registered users is probably much higher at this point.
