The two fatigue protocols were designed to produce either (a) a non-specific widespread fatigue of trunk and limb muscles (e.g. rowing fatigue protocol), or (b) a specific fatigue of the trunk extensor musculature (e.g. back extension fatigue protocol).
(2) In the absence of environmental stimulus to differentiate, non-specific widespread amplification of transcriptional noise in this case, amplification of noise in the expression of all 6 genes is also sufficient to trigger stochastic transitions to the pluripotent state.
In addition to confirming a central role for OCT4 and SOX2 in reprogramming by defined factors, our model also suggests that non-specific widespread amplification of transcriptional noise may aid reprogramming of somatic cells to a pluripotent state.
Using whole genome bisulfite sequencing, we identified species-specific, widespread and mitotically heritable changes in DNA methylation in response to Pi starvation that are particularly enriched at stress responsive genes.
What follows is a plea about a specific, if widespread, series of health problems; but it's also a parable about the short-term nature of our debate on the NHS, and about value for money, investment and austerity economics.
It was established here using a phylogenomic approach that systems of this kind are specific but widespread in Firmicutes, where they originated.
In conclusion, the present findings implicate MF cortex as the fulcrum of a neural network involved in monitoring behavior for errors and theta-band oscillations as a putative neurophysiological mechanism by which MF cortex engages specific and widespread networks for implementing flexible performance adaptation.
Indeed, it is not know whether the primary pathology of the illness is region-specific or widespread and data has been provided for both cases [10], [36].
Subgroups of survivors with domain-specific and widespread unmet needs were identified.
Thus, they often lead to non-specific and widespread effects that would make their clinical application difficult.
