This was assessed by a specific VAS tolerability questionnaire and by data relating to adverse events.
Carfilzomib has shown specific long-term tolerability in follow-up of the pivotal 171-003-A1 trial, as well as an extension trial in which patients who completed other carfilzomib studies are eligible to enroll (PX-171-010, NCT00884312) [ 17, 29].
Therefore, we think it is reasonable to judge and compare blood glucose lowering medications, as well as combinations of such agents, primarily on the basis of their capacity to decrease and maintain A1C levels and according to their safety, specific side effects, tolerability, ease of use, and expense.
Most authorities recommend a trial of topical glaucoma medications which are intended for long-term use in order to assess patient-specific effectiveness and tolerability.
These doses did not cause specific adverse reactions and tolerability was good.
This tool is specific for ophthalmic medication tolerability and has good internal consistency, reproducibility and reliability.
The initial choice of drug class and combination could thus rest on price, tolerability, and specific contraindications in individual patients.
However, such an application presents significant logistical and technical challenges and is associated with specific difficulties, including patient tolerability and sleep-stage interpretation in patients experiencing complex electrophysiological changes [ 17].
Secondary endpoints include time to doubling of prostate-specific antigen (PSA) and tolerability.
Tolerability: Differences in specific side effects including but not limited to cognitive impairment, diarrhoea, gastric irritation, nausea, haematological abnormalities, hypothyroidism, hyperparathyroidism, polyuria, non-toxic rash, somnolence, lethargy, thirst, tremor, weight gain.
