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Next, we sought to determine a relationship between MLK4 mRNA levels and the specific subtypes of breast cancer.
Here we demonstrate a critical role for PTK6 in anchorage-independent survival of specific subtypes of breast cancer cells.
However, the role of LOXL2 in specific subtypes of breast carcinomas has not yet been established.
We next determined whether the upregulation of U6 and 5S observed above is unique to specific subtypes of breast cancer.
The present analysis is the largest yet conducted of OC use in relation to specific subtypes of breast cancer among African American women.
The ability to predict breast cancer risk may then be improved when models are used to predict specific subtypes of breast cancers.
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To find the association between MLK4 expression and the specific subtype of breast cancer, we performed a transcriptomic analysis of multiple datasets, which showed that MLK4 is highly expressed in triple-negative breast cancer compared to other molecular subtypes.
However, major amplification of MLK4 was identified in patients with triple-negative breast invasive carcinoma and the lack of targeted therapies in TNBC prompt us to investigate the role of MLK4 in this specific subtype of breast cancer.
Few studies have reported an effect of metformin in a specific subtype of breast cancer.
In contrast, VEGFR3 is not enriched in any specific subtype of breast cancer cell lines.
Another limitation for both single and multi-gene signatures is that they are positive in only a specific subtype of breast cancer.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com