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Since FLZM comparative data are available, we also compared our AML specific study sample with normative data from a representative German sample and with data from other cancer patients.
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Studies examining effects in specific study samples (such as diabetic patients with co-morbid depression) were excluded.
The Schmidt and Hunter approach (2003) assumes that all specific study samples are from essentially the same reference population with a single underlying IQ/job-performance correlation having close to zero variance.
In this specific study, the sample size of patients and controls were determined as at least 40 according to α = 0.05 and β = 0.15.
Another approach would be to use a PBPK model to simulate results that are specific to their study sample collection time and PFAS distribution.
However, our study was also limited in several aspects: (1) our cases included both diabetic and non-diabetic patients and therefore the impact of diabetic status was not accounted for; (2) the findings of this study may be specific to the study sample in Asian populations; (3) this was a retrospective study with a small number of patients.
The raw accelerometer data were analysed using KineSoft V.3.3.63 (KineSoft, Loughborough, UK) to derive activity intensities using cut-points specific to the study sample's age group—sedentary behaviour (SB): <100 counts/min; light physical activity (LPA): 100 to <1500 counts/min; MVPA: ≥1500 counts/min.
Although data from the local population were unavailable for age-specific comparisons, the study sample was comprised more from younger children (ages 2-11: 59.3%) than from adolescents and teenagers 12-177: 40.7%).
Since all studies have certain limitations (e.g. only visual analog scale values was reported, no age-specific values reported, small study sample) we decided against using values of one of these studies for baseline utility values within the base-case analysis.
In 66% (33) of articles, samples were from an archive, whereas in 34% (17), samples were apparently collected for the specific study, including five articles in which samples were from phase II trials or RCTs.
We did not assess relationships with specific drugs due to limited study sample size.
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