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Unlike oxybutynin, data from animal studies suggest that tolterodine, although a non-selective antimuscarinic agent, exhibits preferential organ specific selectivity to M2 and M3 muscarinic receptors found in the bladder, accounting for an improved side effect profile with respect to the occurrence of dry mouth.
Furthermore, natural products have specific selectivity for cellular targets [ 26], with biologically active natural products providing selective ligands for disease-related targets [ 27].
The groove recognition was highlighted to elucidate the specific selectivity.
S6 showed excellent fluorescent specific selectivity and high sensitivity for Hg2+ in aqueous solution.
Both probes exhibit high specific selectivity and sensitivity for F− compared to other anions.
A majority of them displayed significant inhibitory potency and specific selectivity over PTP1B.
Similar(19)
shR-P16, which previously demonstrated high efficiency target selection in the full-length hemizygous assay, again showed high mutation-specific selectivity in the heterozygous disease model system, efficiently knocking down the mutant transcript to 7% of control levels (p<0.05) whilst minimally affecting the wild-type (74% of the control levels; Figure 4).
The topless trawl design was developed to improve species-specific selectivity in such fisheries.
Our results indicate that it takes until early adolescence for the domain-specific selectivity of syntax within the language network to develop.
The properties of M-13 bacteriophage can be systemically modified to impart target-specific selectivity and sensitivity using the phage display technique.
For this reason purification fingerprints are introduced in this paper which characterize purification steps or mass separating agents due to their contaminant-specific selectivity in a descriptive and comprehensive way.
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