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The combination of the different effects described above makes it difficult to determine one single TOF gain for a specific scanner.
Fluorescence molecular tomography [FMT] was performed using a wave-type specific scanner for transillumination, reflectance, and absorption as described [20] (FMT 2500; PerkinElmer Inc., Waltham, MA, USA).
Of course, these results are, strictly speaking, only valid for the specific scanner and reconstruction software used in this study, but it can be expected that with other systems, similar SUV deviations would occur.
The IG contain not only detailed acquisition and reconstruction parameters for the research scans of patients in the clinical study, but also guidelines on phantom studies to obtain the necessary approval from the sponsor to use a specific scanner for the study.
Then, each participant was given the same explanation of the implant selection and positioning, using specific scanner software.
Consequently, VOI methods are often being used without proper validation or optimization for the specific scanner at a particular site [ 13].
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In addition to a different energy window, a narrower coincidence window decreases random coincidence rates which is relatively of more importance for I and Y than for F. Use of a narrower energy window, however, may increase the inaccuracy of dead time corrections as described in the previous paragraph, and energy window-specific scanner normalization may be required.
Finally, it should be noted that our detection of novelty effects that were earlier (85 115 ms) than in previous studies cannot be explained by methodological aspects of our analysis (e.g., a potentially higher spatiotemporal sensitivity of SPM for MEG/electroencephalography) or the specific MEG scanner, given that the same method was used in experiments I and II.
Since the segmentation method is completely unsupervised and not input-dependent, the two resulting distributions will be slightly different from subject to subject in terms of count rate, thus avoiding the need to specify a priori information or threshold values that could be subject-specific or scanner-specific.
Could the authors please specify whether they found site-specific or scanner-specific artefactual ICs in their results?
As there were no 90Y PET/CT protocols specific to our scanner make and model in prior literature, our early scan protocols were based on publications of other scanner types [22, 29].
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