Sentence examples for specific repression from inspiring English sources
Amongst heat-repressed transcripts a night specific repression at VS of stilbenoid and phenylalanine metabolism and synthesis can be remarked and confirms observations made in a a previous study [ 53] where a night up-regulation of these pathways was observed under controlled conditions.
For one novel nucleoid-associated protein, FASTKD1, we discovered a role in downregulation of mitochondrial complex I via specific repression of ND3 mRNA.
Mechanistically, we determined that this instability arises because of suppression of the DNA mismatch repair and homology dependent repair pathways, due to specific repression of the MLH1 and BRCA1, genes, respectively.
A second mechanism contributing to PS7 expression of dpp appears not to require Ubx protein directly, and involves a general visceral mesoderm enhancer coupled to a spatially specific repression element.
The sequence specific repression proteins, Ash1 and Ume6 are also stably integrated into the Rpd3L complex [5].
This may be due to the difference between modulating total CELF protein levels and specific repression of CELF splicing activity.
Similar to dCas9, the ddCpf1-mediated target-specific repression was also of high specificity, which was consistent with previous findings that genome editing with the wild-type Cpf1 was of extremely low off-target effect [41, 42].
Sugino, K. et al. Cell-type-specific repression by methyl-CpG-binding protein 2 is biased toward long genes.
We demonstrate that this disconnect is not caused by gene-specific repression through CCCTC-binding factor (CTCF) but instead by aberrant chromatin compaction.
Choo, A. Y., Yoon, S.-O., Kim, S. G., Roux, P. P. & Blenis, J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.
This protocol describes how to design, construct, and experimentally validate the function of sequence-specific single guide RNAs (sgRNAs) for sequence-specific repression (CRISPRi) or activation (CRISPRa) of transcription in mammalian cells.
