In this manuscript we present the first description of an episomal and tissue-specific replicating SMAR-based vector.
The association between decreased serum uric acid and the effect allele of rs6449213 in SLC2A9 was sex-specific, replicating the findings of other investigators [ 36, 37].
We pooled the reads from two lanes to constitute the read counts for a specific replicate (multiplexed with other samples).
Since experiments were independent of each other, specific replicates of a given strain were not directly linked between all of the experiments.
The CMH is sensitive to the specific replicates included, as including the fifth replicate in the optimal sequence actually leads to worse performance than four replicates (Supplementary Fig. S3c and d).
The base model that included a random across-breed animal effect and a within-breed animal effect, was run once for each specific replicate in this scenario and the total genetic variance was calculated.
A single-cell suspension of M. tuberculosis was exposed to a test agent or a dimethyl sulfoxide (DMSO) vehicle control for 7 days in 96-well microplates containing 200 μl liquid medium specific to replicating or nonreplicating conditions.
Sensitisation is specific to replicating cells and, importantly, ATR inhibition selectively sensitised cells that are defective in the G1 checkpoint, for example, by virtue of p53 mutation (Cliby et al, 1998; Nghiem et al, 2001).
As for the various datasets of seed-specific genes screened by DDD-alone, microarray-alone and DDD + microarray, the qualities of these lists were all evaluated by the specificity (% of wheat seed-specific genes replicating in rice) and sensitivity (% of rice seed-specific genes replicating in wheat) analysis (Table 2).
Tyrex2 was then used to regulate adenoviral E1A expression to construct a melanoma-specific replicating adenovirus.
The MLP may be a useful promoter in the context of a tissue-specific replicating adenovirus.
