Bill Milbrodt from Howell, N.J., wrote, "if you are in the information-delivery business and want a message to have a specific twist brewed for a specific predilection, this is one hell of a story to learn from".
The reasons for the specific predilection of HCV for infecting exocrine gland tissue are unknown.
However, a sex specific predilection to risk factors for venous thromboembolism, apart from use of hormonal therapy and pregnancy, seems unlikely.
In addition to plaques and neurofibrillary lesions, the AD brain is also characterized by massive neuronal cell and synapse loss at specific predilection sites (Selkoe, 2002).
Limitation to IgG3 in our three cases confirms the specific predilection for IgG3 to precipitate and self-aggregate in the glomeruli given its properties of high molecular weight, positive charge and complement activation capacity [ 7].
This staging is a feature one definitely would like to recapitulate in animals, as neuronal and synapse loss at specific predilection sites causes the clinical features that discriminate AD from FTD.
SB100X has a number of advantages over virally mediated gene delivery: it integrates transgenes exclusively into TA dinucleotides with specific predilection for dinucleotides that have distinct structural features, integrates transgenes with high efficiency, results in stable integration, integrates large inserts, and does not primarily integrate into transcriptional sequences [ 42– 42].
Both possibilities may be active in this case, resulting in an apparent context-specific predilection for ISCU1/2 to be subject to net down-regulation.
Furthermore, in the commonly used Han:SPRD rat model, where the mutation is in the Pkdr1 gene [ 11], there appears to be a male gender-specific predilection for p21 attenuation, which is consistent with observed gender dimorphism of disease severity in clinical and experimental studies [ 12, 13].
Instead it appears likely that differential expression of a range of genes between M. tuberculosis and M. bovis explains their specific host predilections.
