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We determined the specific potency of the two mAbs with the highest binding affinity against sites 1 and 2, 1269 and 1245, respectively (Feed #1 and #2; Fig. 7a and Supplementary Table 11).
This low NP dose was selected as a stringent test based on the high and specific potency of targeted LIF-NP for inducing OPC differentiation in vitro.
It should be noted that compounds 21 and 23 have been disclosed in the patent literature; however, no specific potency data was reported for any receptor.
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In 2070, however, new technologies were developed which evaluate the whole body field and how to individualize medicines and specific potencies.
The synthesis was highly convergent and required no HPLC purification to obtain the final folate taxoid conjugate 1. Conjugate 1 demonstrated highly FR-specific potency (IC50 2.1–3.5 nM) against a panel of cancer cell lines, with a >1000-fold >1000-foldn cytotoxicity against normal human cells (IC50 >5000 nM).
The human antiserum for use in infants, BabyBig (MassBioLogics, Boston, MA), has a BoNT/A-specific potency of 3,000 LD50/mg [27].
Study-specific potency estimates are highly heterogeneous, and current and previous efforts (e.g., Berman and Crump 2008a, 2008b; Hodgson and Darnton 2000; Lash et al. 1997) to explain inconsistent potency estimates have only partially explained their variance.
Recent literature suggests that the binding affinity of vitamin D2 and its metabolites to plasma vitamin D binding protein is weaker than that of vitamin D3 [ 47, 48], but little is known about the physiologic effects or ethnic-specific potency of vitamin D2.
Only further research will satisfactorily clarify the controversial issue of fiber-specific potencies and, furthermore, is warranted considering the politically sensitive nature of this question and the widespread public health impact of historic and current asbestos use.
However, exposure assessment limitations likely contributed to heterogeneity in study-specific potencies as well, because of attenuation of exposure response relations (KL values) resulting from varying degrees of misclassification of exposure.
They proved to be reasonably potent and fairly specific, with potency to specificity ratios of 7.98 and 6.42, respectively.
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