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However, protein-protein interactions (PPI) are not identified in a specific physiological state and thus may capture interactions or regulations during embryonic development.
In a previous study, the calcifying uterus was compared to 2 other segments of the oviduct not involved in shell formation (magnum and white isthmus secreting egg white and eggshell membranes respectively), which demonstrated that the uterine transcriptome in this specific physiological state consisted of 605 differentially expressed genes [ 19].
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Here we review the diverse mechanisms cells use to adapt metabolism to specific physiological states and discuss how metabolic flux analyses can be applied to identify important regulatory nodes to understand normal and pathological cell physiology.
Its cellular accumulation is in response to specific physiological states - like deficiencies in amino acid, Pi, nitrogen or to the more general stresses akin to a nutrient downshift or high salt.
Microarrays have successfully identified many of the genes and regulatory factors related to specific physiological states in poplar.
Three consecutive stages, each associated with specific physiological states of the cells, typical morphological features and expression of specific sets of genes have been described during the process of trans-differentiation of Zinnia cells.
The biological feasibility of these approaches is highlighted by animal breeds that are inherently more resistant to some forms of diseases or parasites as well as specific physiological states that highlight disease susceptibility [ 18, 19].
This component complements other recent scholarship in race and medicine that has explored other specific physiological and disease states, such as lung capacity, cancer, schizophrenia, and heart disease.
To our knowledge, only miR-483 has been previously associated to a specific disease or a physiological state and was found to be significantly correlated with cardiac hypertrophy [52].
We stress the fact that the definition of persistence presented here is not directly linked to a specific mechanism or to a physiological state of the bacteria.
Acclimation may prove to be a distinct physiological state, with specific energetic costs that merit further study.
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