"The patient's own mind, or thought, was able to drive the movement in the legs," said Dr Kendall Lee of the Mayo Clinic, one of the principal investigators of the study, but he stressed that much about the mechanism remained unknown".You have to deliver a very specific type of stimulation parameters.
The patterns of stimuli predicted under normal muscle contractions indicated that several territories and tissues developing within the interzone experience specific patterns of stimulation [initially described in 30, Figure 5].
Such diversity supports the concept of relatively specific effects of stimulation areas in manual therapies of rehabilitation medicine [ 65] and acupuncture [ 66, 67].
In spite of these difficulties, it was recognized that subdural placement of the electrodes improved electrical coupling to the spinal cord [ 28] and was particularly important when the specific site of stimulation on the dorsal columns was critical [ 29].
This notion was highly supported by the findings in which the vmPFC synapses are potentially vulnerable to LTP or LTD strengthening after specific type of stimulation (Herry and Garcia, 2002).
In a few odd cases, asymmetric cell count on the two sides was observed but the asymmetry was not restricted to any side and thus not related to the specific direction of stimulation.
In slices, specific patterns of stimulation to the Schaffer Collateral can induce long-lasting increases and decreases in synaptic strength, termed long-term potentiation (LTP) and depression (LTD) respectively.
Therefore, accurate, participant-specific localization of stimulation sites on the scalp is required for optimal stimulation [ 6].
The dominant site-specific features of stimulation applied at the swing to stance transition were effects on TA muscle activity and force detected at the heel FSR.
Today, their industrial application is increasing rapidly especially for their capability of specific stimulation of beneficial bacteria.
