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Several genetic associations have been observed between HLA types and autoantibody profiles, and genome-wide screening studies identified specific nucleotide polymorphisms in relevant genes related to SSc.
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The ALHF allele specific primer pair was designed based on the specific sequence of the genes from ALHF by placing a specific nucleotide polymorphism at the 3' end of each primer to permit preferential amplification of specific alleles from ALHF.
One of each allele specific primer pair was designed based on the specific sequence of the genes from ALHF by placing a specific nucleotide polymorphism at the 3' end of the primer to permit preferential amplification of the allele from ALHF.
Hybridization probes were designed on the basis of the most variable window approach, which identified species-specific nucleotide polymorphisms in a region of generally high sequence similarity.
M6P/IGF2R loss of heterozygosity in locally advanced squamous cell carcinoma of the head and neck was assessed with six different gene-specific nucleotide polymorphisms.
This is in line with findings that cytoplasmic proteins and proteins involved in cellular metabolism are also less frequently affected by phospho-specific nucleotide polymorphisms [ 62].
The advantage of the ArrayTube or ArrayStrip is that minimal DNA is required for amplification, and the hybridization patterns indicate species-specific nucleotide polymorphisms in regions of high sequence similarity.
The oligonucleotide primers were chosen from a 500-bp genomic fragment which is well conserved in M. bovis and the pncA gene (based on M. tuberculosis-specific nucleotide polymorphism, a cytosine residue at position 169), specific for M. tuberculosis.
102 Specific single nucleotide polymorphisms seem to be associated with specific clinicopathological features.
We hypothesized that combinations of specific single nucleotide polymorphisms (SNPs) in the 3′untranslated region (3′UTR) of HLA-G play a role in unexplained recurrent miscarriage.
There is at present no consensus on specific single nucleotide polymorphisms or halpotypes associated with the particular candidate gene loci in these illnesses.
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