Sentence examples for specific modes of action from inspiring English sources

In this study, the total toxic effects of river water samples were assessed using a series of cell culture bioassays which encompassed different mechanisms, based on specific modes of action.

The cytotoxicity based trigger value cannot be used in isolation, it must be applied in conjunction with effect-based trigger values targeting critical specific modes of action such as estrogenicity or photosynthesis inhibition.

In most cases, these compounds are characterised by highly specific modes of action, and the evolutionary conservation of drug targets in wildlife species suggests the possibility that pharmaceuticals present in the environment may cause toxicological effects by acting through the same targets as they do in humans.

Passive and composite sampling in combination with in vitro bioassays and identification and quantification of individual chemicals were applied to characterize pollution by compounds with several specific modes of action in urban area in the basin of two rivers, with 400,000 inhabitants and a variety of industrial activities.

Consequently, current EU projects are investigating the contribution of zebrafish bioassays for water quality assessment and EDA of environmental samples, with focus on specific modes of action, mechanism-specific endpoints and adverse-outcome pathways [28,29].

We therefore established a workflow based on molecular dynamics (MD) simulations to cover the whole spectrum of structural flexibility and incorporated it into multiple pharmacophores that represent specific modes of action.

One key requirement for modern pharmaceuticals is a specific mode-of-action with little or no side-effects in vivo.

Although there are seven types of the toxin, each with a specific mode of action, just two, A and B, are currently used medically.

Pharmaceuticals are designed to have a specific mode of action and many of them are persistent in the body.

There is growing evidence that trial designs that consider the specific mode of action of these compounds are of crucial importance for their clinical testing.

Conclusion: Generation of eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells may permit the broadening of cancer gene therapy strategy, particularly because of the specific mode of action of anticancer plant proteins.