"Dressing in a specific manner such as a schoolgirl in a uniform".
When crossed to flies carrying a source of the transcriptional activator Gal4 expressed in a tissue specific manner, such as ap-Gal4, the EP line drives the expression of the gene(s) it is inserted next to (Fig. 1A) [20], [20].
For example, some stakeholders were unfamiliar with the concept that different users see information in specific manner such as individual or aggregate views.
Recent evidence indicates that estradiol synthesis can occur within the developing rat brain [2], particularly within the hippocampus, suggesting that it may be possible for SKF 38393 or PSK 3668 to alter local estradiol synthesis in a region-specific manner, such as the BST and CeA but not the mPOA or hypothalamus.
Primordial germ cells undergo a nearly complete epigenetic erasure, followed by reprogramming of DNA methylation patterns in a sex-specific manner, such as at imprinted genes [ 9– 11].
Many approaches for detecting DNA methylation are done in a gene-specific manner, such as bisulfite treatment of DNA combined with sequencing, amplification by methylation-specific PCR, or restriction enzyme-based digestion.
The use of these technologies in a drug-specific manner, such as the study carried out by Cui et al. [ 98] to map PCN-induced PXR binding sites in mice, will provide the opportunity to highlight drug response-associated regions in these whole-genome datasets.
It has become evident that expression of many KLKs is regulated by steroid hormones in a tissue-specific manner, such as KLK2, PSA/KLK3 and KLK4 by androgen in prostate and breast cancer cells, and KLK4 by estrogen in endometrial and ovarian cancer cells [ 49– 52].
Another promising direction for future experiments will be to look at the interactions between sexual differentiation genes and the pathways and interventions that are known to regulate life span in a sex-specific manner, such as the insulin/IGF1-like signaling (IIS) pathway and dietary restriction (DR) [ 8, 10, 11].
Establishment of these long-lasting changes requires gene expression and synthesis of new proteins [ 7- 9] in a time-dependent and region-specific manner; such changes may serve as early markers of drug-activated biological processes.
More than 20 members of the cadherin molecules have been reported with cell type-specific expression manner such as E-cadherins in epithelial cells, N-cadherins in mesenchymal cells (such as stromal cells), VE-, P-, and R-cadherins in vascular endothelial, placental, and retinal tissues, respectively.
