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On the contrary, most of the fluvastatin-treated cells displayed a weak anti-p21 ras immunoreaction localised mainly in the cytoplasm; no specific localisation of the p21 ras peptide was observed at the level of the plasma membranes or nuclei.
The method provided a highly specific localisation of the HMFG1 epitope to the ciliated and 'ciliogenic' cells of the endometrial surface.
This hypothesis is sustained by the specific localisation of c-Yes in cholesterol-enriched microdomains found at adherent and tight junctions, probably due to an additional palmitoylation site present in c-Yes.
However, the specific localisation of just one other crucial component could dictate the targeting of secretion.
Previous studies reported tissue specific localisation of plant dehydrins under stress conditions [ 13].
In 1976, Khaw et al. [ 36] reported a specific localisation of a purified antibody against cardiac myosin.
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Ito, D. et al. Microglia-specific localisation of a novel calcium binding protein, Iba1.
The cell-specific localisation of individual CYP enzymes in the lung is poorly understood.
Owing to the tumour-specific localisation of drug, the 0.008- μ value likely underestimated the concentration of ANG1005 within the glioma itself.
In Barrett's carcinoma (figure 6Di and ii) LGR5 mRNA shows a specific localisation at the bases of the malignant glands (n=5).
Moreover, the identification of specific localisation patterns in fertile males, and their precise functional roles, would provide a key benchmark to which infertile sperm may be compared.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com