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These more specific linkages are discussed in the sections that follow.
However, the only specific linkages are of Gly855Arg with ethinylestradiol, and Asp676Tyr with fluvastatin-induced liver injury (Russmann et al. 2010).
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That specific linkage is startling and arresting, but it is also revealing of Thomson's intent to do more than play fanzine games.
It will be of interest in future studies to determine whether this specific linkage is found in glycans from Ao38 cells.
Chromosome 4 and 16 linkages are specific to female affected families with hip OA who had undergone total hip replacement (THR) [ 30]; chromosome 2q linkage was found in distal interphalangial joint OA [ 33], knee OA [ 34] and hip OA [ 35]; and 11q linkage is specific to female OA [ 36] and hip OA [ 37].
However, these linkages are project-specific, limiting the breadth of influence, and also do not encourage governmental buy-in since governmental actors do not usually take an active role in deliberations.
Double-labeling of sections of the porcine trachea and lungs (Figure 1) revealed that both MAA lectin, specific for Siaα2-3Gal linkandSNAand SNA lectin, specific for Siaα2-6Gal linkages, were stained in both the upper and lower parts of the trachea and in the lung with SNA binding being more dominant than MAA binding.
Also DUBs harbour UBDs and the recognition and binding of a certain UBD to a specific ubiquitin linkage is thought to be essential for specific chain hydrolysis 45.
It still remains to be ascertained whether such a system of linkages is specific to domesticated species (and therefore has the potential to help explain why so relatively few species have been domesticated, despite multiple opportunities existing for additional species) or is in fact a more general effect brought about by directional selection.
Spectroscopic data support the conclusion that the phenolic groups are covalently grafted at the amine site of chitosan although specific linkages could not be established due to the complexity of the chemistry.
As a result, all SGA screens show linkage in the corresponding areas of chromosomes V and XIV and gene-specific linkages cannot be reported (gray areas in Figure S1, panels V and XIV).
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