From our analysis we projected that maximally 11% of imprinted genes would be subject to allele specific imprinting.
An association between assisted reproductive technique (ART) and specific imprinting mutations, such as Beckwith-Wiedemann syndrome (BWS), has recently been documented.
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This lack of conservation often occurs where there is placental specific imprinting [9], [16].
The question of placental specific imprinting in the human has not been answered fully.
Human gestational load is less than in the mouse, resulting in reduced need for maternal resource competition, and therefore maybe also a lack of placental specific imprinting.
However, as early development is less divergent between species, placental specific imprinting may be present in very early gestation in both mice and humans.
Similarities restricted to early human and mouse gestation could include the phenomenon of placental specific imprinting, and therefore require analysis of early placental development.
These results indicate that the Atp10a gene is biallelically expressed in the tissues examined although the possibility of cell-type specific or developmental stage specific imprinting cannot be ruled out.
To examine whether there was a quantitative or gender specific imprinting expression of Atp10a, we also performed real-time RT-PCR analysis for Atp10a in cerebellar tissues from m−/p+ and m+/p+ mice of both sexes.
The reason why some animals were more affected than others is not clear but could hint at the existence of modifier genes or variation in the extent of allele specific imprinting.
