Sentence examples for specific imbalances from inspiring English sources

Any new powers should help address specific imbalances in our system including: new homelessness provisions based on the current impact assessment; reforming tenure in order to deliver a more flexibility and efficiency; and, new powers to intervene in the private rented sector to improve quality.

A third of those loans lack the standard covenants that limit how much debt the borrower can carry.Ms Yellen said such trends are not troubling enough to affect the course of monetary policy for now; she prefers that they be dealt with through "macroprudential" policy, meaning regulations designed to address specific imbalances in the financial system.

Using the observed variability between technical and biological replicates, we established an average sensitivity limit of 1.2 for detecting allele specific imbalances.

However, mutant allele specific imbalance (MASI) has been observed in tumors and cell lines harboring mutations of oncogenes.

A fourth pattern, reverse MASI, defined as wild type allele specific imbalance (mA/wA<0.5) was present in only one line (1%) having a mEGFR.

While activating somatic mutations in one allele of an oncogene (heterozygous mutation, "one hit") is generally believed to be sufficient to confer a selective growth advantage on the cell [1], mutant allele specific imbalance (MASI, Fig. 1a) has been observed in tumors and cell lines harboring oncogenic mutations.

Recent studies report a mutant allele specific imbalance of oncogenes in tumor cells harboring gene mutation; copy number gain of EGFR usually occurred in the cells with an EGFR mutation[ 32].

In fact, a recent paper noted that 12/14 APC- mutation positive families in whom the mutation was located before the last exon of the gene had allele specific imbalance at the mRNA level, which is consistent with a mechanism of nonsense-mediated decay (Castellsagué et al., 2010).

Of 11 gene-specific imbalances only 2 (CCNEI, CDK4) resulted amplified at a higher rate in our study.

Recently, a significant allele-specific imbalance was identified in the 16q23 region in a cohort of HCC patient due to LOH.

KRAS mutant allele-specific imbalance has been reported to correlate with progression to undifferentiated carcinoma of the pancreas [19], and expression of granulocyte/macrophage colony stimulating factor (GM-CSF) to correlate with KRAS mutations in pancreatic tumors [20].