To mimic the human syndrome a model would need to be characterized by the development of pregnancy-specific hypertension, proteinuria and associated alterations in vascular function and biomarkers.
Therefore, this scale has been suggested as suitable for use in studies specific for hypertension in a predominantly black population.
Comorbid burden at baseline was measured by the Deyo-Charlson Comorbidity Index and presence of the following specific conditions: hypertension, dyslipidemia, respiratory disease, renal disease, and arthritis.
Focusing on specific comorbidities, hypertension - the most frequent comorbidity in this population - has not been found to influence any of the HRQOL domains.
We also explored alternative models controlling for patients' overall number of medications and number of medications for specific comorbidities (hypertension and hyperlipidemia) as potential confounders.
The assessment of comorbidities included nine specific conditions: hypertension, myocardial infarction, lower extremity arterial disease, major neurological problems, diabetes, gastrointestinal disease, chronic respiratory disease, kidney disease, and poor vision.
Indicative of VEGFR inhibition, pazopanib decreases sVEGFR2 and increases PlGF levels, and changes of both factors are associated with the pazopanib-specific toxicities hypertension and TSH elevations.
Fifteen studies of patient subpopulations (eg, other medical conditions) or specific subclassifications of hypertension (eg, masked hypertension) were omitted, leaving 78 studies in 77 articles for inclusion in this review.
Furthermore, in the specific case of hypertension, various longitudinal population-based studies have suggested that the relationship between hypertension and cognitive decline is not linear [ 26, 27].
Finally, this is the first study demonstrating a specific association between hypertension and lipid profiles.
Patients were asked to report the presence of specific comorbidities including hypertension, myocardial infarction, heart failure, cardiac arrhythmia, stroke, asthma, chronic obstructive pulmonary disease (COPD), diabetes and depression.
