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It's set at a specific hinge of history: the day of the German surrender, with the Communist assumption of power well under way.
The conformational rearrangements are shown to involve specific "hinge residues" in the transition between the occluded and the inward-facing states.
That specific hinge regions enable the dynamics of propagation of the observed allosteric effects was established first for the unwound regions of TMs1 and 6.
Specific hinge regions within the TMs (TMs2, 7, 10 and 11) enable the resulting large-scale segment rearrangements that characterize the resulting transition from the occluded to the inward-facing state.
The key point is that rotations will be locally controlled at specific hinge sites, whereas a translational motion would not be controlled at specific sites.
Upon transfection of the N-terminal chimeric aPKCιN-ζHINGE/GFP fusion protein into MDCK cells it became apparent that the aPKCζ specific hinge sequence is able to keep the aPKCι protein outside of the nucleus (Fig. 5A,C).
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This specific hinge-like structure of TSP1 domain may play a vital role in binding activity with the receptors.
To investigate whether MMPs catalyze specific single hinge cleavage of trastuzumab, a panel of four human MMPs were individually incubated with trastuzumab in vitro, and hinge cleavage was detected using a capillary electrophoresis separation system.
To be more specific, the hinge loss of the projected nodes takes the minimal value when dimension is 2 on the MemeTrakcer dataset and 1 on the Sina Weibo dataset.
The precise response of an estrogen receptor to a specific ligand hinges on the cellular context and the presence of cofactors, and it's still unknown whether in vitro observations reflect what happens in vivo.
Analysis of volatile aromatic compounds during grain ripening identified odor-active compounds (OAC), including 2AP, decanal, pentanal, phenylacetaldehyde, hexanal, (E -2-nonenal, nonanal, hE -2-nonenalctanol, 1-octE -2-nonenal 2-penonanalan as contributors toward theptanale sensory of specific rice fragrance (Hinge et al. 2016).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com