Exact(8)
Human monoclonal antibodies 447-52D and 537-10D, both coded by the VH3 gene and specific for the third variable region (V3) of the HIV-1 gp120, were found to share antigen-binding structural elements including an elongated CDR H3 forming main-chain interactions with the N terminus of the V3 crown.
Vaccine-elicited antibodies specific for the third hypervariable domain of the surface gp120 of human immunodeficiency virus type 1 (HIV-1) (V3 loop) were assessed for their contribution to protection against infection in the simian-human immunodeficiency virus (SHIV /rhesus monkey model.
Subsequently, human mAbs, representing conventional Abs made by most chronically infected individuals, were shown to neutralize multiple lab-adapted and/or primary isolates in vitro (23 29), and two of these mAbs, specific for the third variable region (V3) of the HIV gp120 envelope glycoprotein, provided protection against heterologous HIV strains in relevant animal models (30, 31).
7C8 is a mouse monoclonal antibody specific for the third hypervariable region (V3) of the human immunodeficiency virus type 2 (HIV-2 -associated HIV-2 -associated
The three-dimensional crystal structure of the Fab fragment of the mouse monoclonal antibody 7C8, specific for the third hypervariable region (V3) of gp125, reveals a deep and narrow highly hydrophobic antigen-binding cleft with architecture appropriate for a linear epitope.
Similarly to the effect of CREB count, the effect of CNS count was highly specific for the third eigensystem (data not shown).
Similar(52)
Antibodies specific for the second antigen are of primary-response quality while the antibodies which cross-react with the first antigen are of secondary-response quality.
Two of the DNA fragments specific for the first clade contained a partial operon for pyrroloquinoline quinone (pqq) biosythesis.
To test this, we performed RT-PCRs on Helicosporidium RNA treated with DNAse using primers specific for the second and third cox1 exons.
After amplification with primers specific for the second CpG island, we observed TSA increased the acetylation of both histones H3 and H4 (to lesser extent) which interacted with the VILIP-1 promoter (Figure 4B) in all six cell lines studied.
Again, the effect was specific for the first gestational month.
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