For intracellular delivery siRNA into activated endothelial cells, formulation with SAINT-C18 was a necessity to induce a specific down-regulation of gene expression of VE-cadherin.
Conditional and specific down-regulation of FTA in canola using the AtHPR1 promoter driving an RNAi construct resulted in yield protection against drought stress in the field.
Specific down-regulation of MMP-8 in non-metastatic NM-2C5 cells resulted in a 2.5-fold increased capacity to invade through Matrigel.
But it fails to be induced by low temperature in thermosensitive genic male sterile lines, suggesting that specific down-regulation of TaAnn10 is associated with cold induced male sterility in wheat (Xu et al. 2016).
Results from both gain-of-function and loss-of-function experiments in this study support the notion that specific down-regulation of cytokinin oxidase 2 expression enhances rice yield by increasing tiller number and grain weight.
Thus, the results from both gain-of-function and loss-of-function experiments support our conclusion that specific down-regulation of cytokinin oxidase 2 expression enhances rice yield by increasing tiller number and grain weight.
Subsequently, the model was validated through experimental analysis of a specific down-converting borate glass co-doped with Ce3+ Yb3+, whose optimal thickness has been determined to be 0.83 mm.
In a control experiment, the expression of RanBP2 slightly increased under the same conditions, thereby indicating a specific down-regulation of Pias3 among the SUMO E3 ligases.
In fact, we have previously shown specific down-regulation of QKI-7 in the prefrontal cortex (PFC) of schizophrenia patients [6].
