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These histidine-functionalized interfaces are designed to allow specific docking and fusion of vesicles containing metal-chelating lipids.
We showed that one device used by the cell for discrimination between parallel MAPK pathways is a specific docking interaction between a MAPK and the N-terminus of its cognate upstream protein kinase (MEK).
Like with mersacidin blocking of lipid II inhibits peptidoglycan biosynthesis; in addition, lipid II is used as a specific docking molecule for the formation of pores.
The CW-based model is used to predict the proximity trajectory, while a receding prediction horizon is employed to complete the specific docking manipulation in finite time, and a 2-norm cost index about control input is used to minimize the fuel consumption of the chaser during docking.
The default AD4 behavior is to load all grid maps required for a specific docking into memory from the file system and to release that memory at the end of the docking.
But, if such can be achieved in a representative sample of cases, kinase-substrate specific docking algorithms may be able to do the rest.
Of importance, calmidazolium has explicit positive charge, and electrostatic interactions may be required for specific docking at the pore loop of TRPV1 (Figs. 10 and 11).
We also demonstrate that the phosphorylation of Tyr120 creates specific docking sites for the SH2 domains of both Vav1 and Fyn, a condition sine qua non for the optimal association of these two signalling proteins in vivo.
These specific interactions are due to the presence of specific docking sites in Pbs2.
The presence of group specific docking domains in MAPKs suggests that different MAPKs targets are group specific.
Alternatively, membrane targeting in metazoans may represent the first targeting step that precedes a more specific docking event.
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