Sentence examples for specific disruption of the from inspiring English sources

These behavioral effects of Afh mutation were complemented by the specific disruption of the Per/Cry circadian regulatory complex in brain regions that govern food anticipatory behaviors, sleep, and timing.

We also show that FilGAP interacts exclusively with FLNa among its homologs and specific disruption of the FLNa-FilGAP interaction perturbs cell spreading.

The levels of ATG5 on the other hand were not significantly changed, arguing for a specific disruption of the PI3K complex in AD rather than a general deficiency in the autophagy pathway and signaling cascade.

Mice with fat specific disruption of the insulin receptor have reduced obesity [ 18].

Second, the specific disruption of the iconic trace should have no effect on the last item in the sequence, as no additional items were presented subsequently.

We also determined whether specific disruption of the ARE abolished the ability of Nrf2 to induce luciferase from the miR-125b-1 miR-125b-1 miR-125b-1

Specifically, our model reproduced the distinct migration stages in the known cortex zones [ 37], bipolar and multipolar cell states over time [ 1, 2], cell population dynamics [ 17, 38], and specific disruptions of the migration induced by manipulations of the key regulators, Lis1 and DCX [ 24, 27].

Studies in mice carrying fat-specific disruption of the insulin receptor gene (FIRKO mice) demonstrated how the insulin signaling pathway plays a major role in the homeostasis of adipose tissue, while its subversion leads to pathological conditions.

Muscle-specific disruption of the p38γ gene, but not that of the p38α or p38β gene, significantly attenuated endurance exercise-induced COX IV and Cyt c expression in p38γ MKO mice, providing genetic evidence that the p38γ gene is required for endurance exercise-induced mitochondrial biogenesis in skeletal muscle.

Similarly, adipose tissue-specific disruption of the insulin receptor (FIRKO) displayed reduced adiposity.

Mice with CD-specific disruption of the ET-1 gene were generated as previously described [ 7].