Exact(33)
"You can't predict what the specific disruption there will be, but you can be sure there will be some disruption," he said.
Their specific disruption affects cell growth and mRNA deadenylation and decay in vivo in yeast.
Curing CHB will require novel strategies for specific disruption of cccDNA.
The structural model and mutagenesis data presented here also provide an opportunity to dissect the functional consequences of specific disruption of DAXX-ATRX in vivo.
Directly inhibiting or activating the function of a transcription factor requires specific disruption or recruitment of protein protein or protein DNA interactions.
Rationally designed therapies aim at the specific disruption of critical signaling pathways activated by malignant transformation or signals from the tumor microenvironment.
Similar(27)
These results indicated that myeloid-specific disruption of RBP-J resulted in attenuated renal fibrosis in mice.
The results provide the first evidence for PCB congener-specific disruption of reproductive neuroendocrine function in a vertebrate species.
Consistent with this, fat-specific disruption of this signaling pathway led to extended lifespan and improved metabolism (Bluher et al., 2003; Katic et al., 2007).
Here, we demonstrate that skeletal muscle-specific disruption of KATP channel function in transgenic (TG) mice promotes production and secretion of musclin.
These data confirm that transient, region-specific disruption of synaptic transmission during early development can have long-term effects on behaviors relevant to neurodevelopmental mental disorders.
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