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Some miRNAs are characteristic of specific differentiated cell types, whereas others are specifically expressed in stem and progenitor cells during early development (Lim et al, 2003; Chen et al, 2004; Poy et al, 2004; Chang and Mendell, 2007; Hwang and Mendell, 2007; Ibarra et al, 2007).
The tumor cells may show certain features of differentiation, but the cells are not equivalent to any specific differentiated cell-type, and seem to occupy a primitive developmental state that precedes the development of embryonic layers.
Because zpuf-6 labels the first transition state into the planarian epidermis, we wondered whether zpuf-6 + epidermal cells embody a specific differentiated epidermal cell type or whether they still possess the potential to differentiate further.
Scar and replacement fibrosis are thus the result of a specific differentiated MyoFb population.
The neoblast cell population includes pluripotent stem cells4,5 and numerous classes of specialized neoblasts that are progenitors for specific differentiated tissues1.
Our findings demonstrate that fibroblasts can be converted directly into a specific differentiated and functional neural subtype, the spinal motor neuron.
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To derive or obtain tissue-specific differentiated cells from hESCs/hiPSCs, most in vitro hESC/hiPSC differentiation protocols requires an initial spontaneous formation of embryoid bodies (EBs), which is a common and critical intermediate for the induction of lineage-specific differentiation [5] [7].
The mechanisms by which the non-physiological agent DMSO maintains in vitro liver-specific differentiated functions are presently largely unknown7.
Excellent outcomes notwithstanding, hESC-based screening platforms are limited by the difficulties of generating homogeneous and lineage-specific differentiated populations from hESCs while culturing them in large numbers for prolonged periods.
Our results bear also on the molecular understanding of the pathogen-specific differentiated immune response of the MEC.
Published: October 3, 2013 Throughout the life of an animal, organ-specific differentiated cell types are renewed.
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