Enriched transcripts in the pairwise comparison are associated with key biological processes of stage-specific development, such as transition of Mf and L3 to new host.
Therefore, it is possible that one key role of Pros in the larval AMC is to control the expression of genes involved in neuron-specific development such as axon routing and/or neurite outgrowth.
More specific Neighbourhood Development Orders can also be produced by these local groups which will enable specific types of development (such as extensions) to happen without the need for applying planning permission.
However, other locally produced growth factors (e.g. RANK ligand) are also essential at specific times of development such as during alveolargenesis [ 16].
Histone degradation in earlier Eukaryotes has also been described during specific stages of development, such as macronucleus degradation in, for example, Tetrahymena 43.
Their main function involves the regulation of organ-specific growth and development, such as flower development [ 6], ovule development [ 4] and the formation of seed size [ 7], by binding to target sequences gCAC(A/G N(A/T TcCC(a/g ANG(c/t) [ 8].
Equally important for the studies of gene function in the mouse is the use of tissue-specific regulatory systems that allow gene inactivation to be restricted to specific tissues and, in some cases, to specific time points during development, such as the "conditional" knock-out, or the application of antisense techniques.
This suggests that preterm delivery disrupts specific aspects of cerebral development, such as the thalamocortical system.
Apart from the consequences for development in general, social skills deficits predict specific problems later in development such as mood and anxiety problems [ 7].
In this way, it should be possible to match developmental lesions and malformations to specific events in cortical development, such as establishment of the subplate, synaptogenesis, and generation and migration of certain types of cortical neuron.
