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However, whether specific depots are differentially sensitive to sex steroid effects and potential sex-differences in response to these hormones are yet to be systemically investigated.
According to this paradigm, the impact of obesity is determined by the pattern of lipid partitioning (i.e., the specific depots in which excess fat is stored).
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UCP1 is the only exclusively expressed in adipose-specific depots, in particular, the brown adipose tissue (Wu et al., 2013).
The interest in understanding how specific AT depots respond to a weight-loss intervention derives from observations in cross-sectional studies that different AT depots are independently associated with different metabolic risk (31).
Nevertheless, a number of other studies in which specific fat depots have been measured by MRI or computed tomography have raised the possibility that the visceral fat depot, with its circulation draining into the hepatic portal vein, is particularly associated with risk marker variation [ 32– 32].
These data suggest that total body fat is a major contributor to the metabolic sequelae of obesity, with specific fat depots, VAT, and DSAT also making significant contributions.
Our results may lead to identification of therapeutic targets acting on specific fat depots to control obesity.
Controlling for weight loss, reduction of specific AT depots was associated with improvement in metabolic biomarkers.
Whether such a signal exists and is directly related to the specific fat depots themselves is unknown.
In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
It thus remains uncertain how specific AT depots respond to weight-loss interventions in adults with type 2 diabetes.
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