Exact(54)
Interestingly, specific depletion of one polyamine does not result in selective uptake of that depleted polyamine [ 10].
Successful gene silencing by RNA interference requires a potent and specific depletion of the target mRNA.
Specific depletion of double positive (DP) thymocytes triggered the up-regulation of Foxn1.
This was further confirmed in a mouse osteotomy model where a specific depletion of CD8+ T cells led to an improved bone healing [13].
Specific depletion of these calcium stores through inositol 1,4,5-trisphosphate (IP3) receptor activation leads to the apparent displacement of the central mass towards both the cytoplasmic and nucleoplasmic sides of the NPC.
Tumors without target receptor were only slightly affected by SA2E and the reduction in side effects less pronounced indicating specific depletion from the blood by target receptor expressing cells.
Similar(6)
To quantify the tissue-specific depletion, we dissected worms specifically expressing TIR1 in the intestine and determined the depletion.
Whereas depletion of calcineurin in late-stage schizonts demonstrated its critical role in erythrocyte attachment and invasion in vivo, stage-specific depletion uncovered roles in gamete development, fertilization, and ookinete-to-oocyst and sporozoite-to-liver stage transitions.
Liver-specific depletion of SCARB1 has previously been reported in Pdzk1−/− mice [27].
Our results show that muscle-specific depletion of Dlk1 leads to defective muscle development, elevated inflammatory responses, and delayed muscle regeneration.
Retinoblastoma protein is a major determinant of Sertoli cell maturation, and mice with Sertoli cell-specific depletion of RB have progressively dysfunctional testes after puberty [6].
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