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They appreciated the continuity the GP provided, i.e. the GP's acquaintance with the patient and the relatives both before and after the cancer diagnosis and the GP's knowledge of the specific course of disease.
For each patient, the model compares the times of all the possible events and processes the events chronologically, for each individual patient it is allowed to follow a specific course of disease that is reflective of that patient's characteristics and treatment options.
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The specificities of the antibody responses will be determined, on the one side, by the constitution, complexity and variability of the antigenic structures of the parasites and, on the other side, by the immunoglobulin repertoire, and the immune and disease history of the host, and by the specific course of the disease in the individual patients.
Although unlikely in view of the specific course of arterial disease, it cannot be excluded that intracranial arterial dissection is at least partly responsible for the vascular pathology seen in some children with TCA (Chabrier et al., 1998; Sébire, 2006).
The approach tested in this study allows the investigation of a complete history of infections and can thus generate important evidence for pathogen-specific courses of disease and immune responses as well as for the holistic understanding of the interaction of different infections and their role for the development of immunity.
Twenty-five unique disease-specific measures of the course of disease were reported in the 12 RCTs.
They used clinical guidelines and validated tools in most studies to deliver care and monitor and identify disease-specific changes of the course of disease.
Oga et al. examined both the course of disease specific HRQL and of lung function in stable COPD patients within three years [ 36].
Whether this distinction of phenotypes can be also applied for the prediction of the course of disease and specific therapies needs to be carefully evaluated.
Thus, the MBR changes during the course of disease exhibit specific patterns according to the condition's pathogenesis, independently of the choroidal thickness changes during follow-up.
Neuropsychiatric symptoms such as fatigue present early in the course of disease, and specific cognitive impairments can be observed in more than half of patients in the early stages [ 8, 9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com