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It is possible that protein interactions do not involve the complete domain, but specific contact points within the domains.
Aptamers are small and highly structured single-stranded oligonucleotides that bind at high affinity (within the low nanomolar range) to a target molecule by providing a limited number of specific contact points imbedded in a larger, defined three-dimensional structure [1], [2], [3], [4], [5].
These interactions often do not require conformational changes of either protein involved and depend only on few specific contact points.
However, the paucity of structural information describing the interaction between CLR and RAMP1 complicates the task of determining specific contact points between the receptor and its ligands.
Secreted IL-17 apparently exists as a homodimer, but the specific contact points between IL-17 subunits or between IL-17 and IL-17R have never been defined [ 2, 10].
Similar(55)
where Pm is the mean specific pressure at contact points (N/mm2), P is the applied load (N), and d is the mean wear scar diameter (mm).
In order to use an actuator for ultrasonic devices, it must meet specific requirements for contact point movement, i.e., the trajectory of a contact point must have elliptical form.
The main objective of efficacy tests is to determine the number of surviving microorganisms after a specific contact time measured at a defined time point.
For these systems, specific solutions to the problem of distributing perturbation forces to the contact points can be obtained (Bicchi 1994).
Charger contact points.
within the app, or only share specific contact details with specific groups of contacts.
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