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In addition, multiple sequence alignments have shown the specific conservation of this residue among the DNA polymerases that use a protein as primer.
This is in accordance with a virus-type specific conservation of the PA-binding domain of PB1 (Fig. 1) and further highlighted by an overall aa identity of the viral polymerase subunits of less than 35% between FluA and FluB strains.
These 61 uORFs, taken from 43 genes, therefore represent a subset that is highly conserved both in terms of absolute and relative conservation of their UTRs, and in terms of specific conservation of the uORF in closely related species.
Our analysis provides insights into the evolution of group B Sox function, highlighting the specific conservation of shared binding sites and suggesting alternative sources of neofunctionalisation between paralogous family members.
The specific conservation of methylation levels at proximal promoter regions is consistent with a more focused study of methylation levels at ten mouse promoter regions (Lienert et al. 2011).
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As certain amino acids are distinctly conserved in epitopes, we further questioned if there are patterns of position-specific conservation of residues that are unique among the epitopes.
A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions.
The finding of genogroup-specific conservation of HBGA binding interfaces will facilitate the development of rational strategies to control and prevent norovirus-associated gastroenteritis.
In the present study, we show an apparent family-specific conservation of physicochemical residue profiles for short PEXEL-flanking regions (vide infra).
Synapomorphic frequencies found domain-specific conservation of sequence.
(B ) Lineage-specific conservation of epigenetic activity occurs at only a handful of Treg regulatory elements.
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