Sentence examples for specific complement from inspiring English sources
Inherited immune disorders undermine the immune response in a variety of ways: B lymphocytes may be unable to produce antibodies, phagocytes may be unable to digest microbes, or specific complement components may not be produced.
Evidence for and against therapeutic modulation of specific complement pathways in these disorders is presented.
These complement inhibitors target specific complement activators and prevent them from initiating activation and if activation is underway, stop it from continuing [6, 7].
With the revelation that complement plays a crucial role in the pathogenesis of inflammatory tissue destruction, a great enthusiasm has evolved for specific complement inhibition as a novel treatment of human diseases [3, 5, 6, 38].
The current study was designed to investigate the interactions of the opacity phenotype variants of Spn with specific complement pathway activation in a mouse model of acute otitis media (AOM).
Naturally occurring deficiencies of specific complement components highlight the need for a fully functional complement system.
The antigenic activity was monitored by its inhibitory capacity in a specific complement-dependent cytotoxic system.
It was already known that these boundary structures express specific complements of signaling molecules (Fgfs, Wnts, and Bmps) (Furuta et al. 1997; Grove et al. 1998; Hoshikawa et al. 1998; Kimura et al. 2005).
When combined with local fluorescence sensors (e.g., SPR, photo-sensitive nanoparticles), electrical sensors (e.g., piezoelectric circuitry), and mechanical sensors (e.g., cantilever deflection), an array of cantilevers with specific complements can provide a powerful and highly sensitive tool for high-throughput screening of pathologies and therapeutics.
Despite a general understanding of the architecture of the system, though, many of the mechanisms that underlie site-specific complement activation and amplification in vivo are incompletely understood.
In addition, there is no capability yet to measure the level of local tissue site-specific complement activation in patients without performing biopsies to detect products using immunohistochemical techniques.
