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Directional transport of specific cargos is tuned to specific molecular motors and specific cytoskeletal tracks.
At the COPII level, cargo divergence possibly engages p24 proteins, which in yeast have been reported to recognise specific cargos [59].
The mechanisms that target Kinesin to specific cargos outside of the neuron are less well understood.
In the last decade, emerging evidence revealed that autophagy can distinguish and direct specific cargos to the lysosome.
All KIF proteins contain a globular motor domain and a tail domain, the latter being responsible for interactions with specific cargos and adaptor proteins.
Since many synaptic components contain the PIP2 binding domain, PIP2 might function as a signal for synaptic components to ride on specific cargos at the Golgi apparatus.
Similar(52)
Most barges are built for specific cargoes.
Homeland Security says it uses a "layered, risk-based approach" to cargo scanning, which, instead of comprehensive scanning, targets specific cargo thought to be high-risk.
Cargo receptors ensure selectivity by tethering specific cargo to lipidated Atg8 at the isolation membrane.
Understanding specific cargo distribution in differentiated cells is a major challenge.
For instance, researchers can load EVs with specific cargo using electroporation, or by expressing nucleic acids in EV-producing cells.
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