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Most barges are built for specific cargoes.
At the minimum, the intermediate chain isoforms produce functionally distinct classes of dynein complexes that may be separately regulated to carry different specific cargoes.
The results support the assumption that the protein is actively involved in sperm nuclear morphogenesis in O. tankahkeei possibly through bridging the manchette-like perinuclear microtubules to the nucleus and assisting in the nucleocytoplasmic trafficking of specific cargoes.
Thus, duplicated myosins could have specialized in the transport of specific cargoes.
It seems likely that these findings result from cell-specific roles for Rab25 in the trafficking of specific cargoes.
In eukaryotic cells, biochemically specific cargoes comprising of proteins and mRNA are continuously being exchanged across the nuclear envelope (NE) that separates the nucleus and the cytoplasm.
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Homeland Security says it uses a "layered, risk-based approach" to cargo scanning, which, instead of comprehensive scanning, targets specific cargo thought to be high-risk.
Cargo receptors ensure selectivity by tethering specific cargo to lipidated Atg8 at the isolation membrane.
Directional transport of specific cargos is tuned to specific molecular motors and specific cytoskeletal tracks.
Understanding specific cargo distribution in differentiated cells is a major challenge.
For instance, researchers can load EVs with specific cargo using electroporation, or by expressing nucleic acids in EV-producing cells.
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