Sentence examples for specific antagonism from inspiring English sources

However, the effectiveness of specific antagonism of the TRPV1 channel in the treatment of migraine remains unresolved.

The presence of neutrophils is mediated in part by leukotriene B4 (LTB4), and the capacity for LTB4 alone to replicate many aspects of neutrophilic inflammation has provided the focus of drug development toward its specific antagonism.

We are thus tempted to propose that a previously uncharacterized biochemical mechanism may allow for a specific antagonism physiologically existing between the Gs- and Go- mediated signaling pathways.

The importance of each of these pathways is supported by a large volume of experimental animal data, and in some cases, clinical trials utilizing specific antagonism of a proposed biochemical mechanism.

If further studies determine these motifs directly contribute to either the cellular localization or, for STAM-1/2, proper ER export, this would provide support for the idea that ER export signals or their mimics can be used not only to facilitate ER export, but also to promote interaction with COPII vesicles to mediate specific antagonism of the secretory pathway.

Specific antagonism of adenosine-dependent effects by methylxanthines, caffeine, and theophylline originally led to the discovery of these receptors.

In this regard, it was not only an important, but also an unexpected observation, that the osteoblast-specific antagonism of Wnt signalling achieved through transgenic over-expression of Krm2 has such a tremendous impact on bone formation, thereby causing an osteoporotic phenotype, whose severity exceeds the one observed in Lrp5-deficient mice [11].

The significance of dual versus ETA-specific antagonism in the clinical arena remains to be elucidated.

Cysteamine had concentration-dependent effects on meropenem sensitivity in the clinical isolates and type strain of M. abscessus tested, showing some concentration-specific antagonism.

Therefore, they represent a novel therapeutic strategy: specific receptor antagonism may prove beneficial in disease management.

These results also underscore that specific MR antagonism generates similar beneficial outcomes, independently of the model used to induce inflammatory renal tissue damage.