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Recent advances are being made and assays developed which will help in studying this pathway of aggregation, monomer addition, and isolating specific aggregate species [ 98].
Due to their clustering around positions 21 23, these mutations offer a unique opportunity to correlate toxicity to specific aggregate conformers, as point mutations alter the rates of Aβ aggregation, fibril formation, interaction with surfaces, and insertion into lipid bilayers by changing the hydrophobicity or charge following substitution.
The chosen aggregate sizes must comply with a specific aggregate grading curve.
Then, the effective elastic modulus and shear modulus of single-phase composite materials with the specific aggregate size are derived.
Moreover, the long-term skid resistance of pavements depends mainly on the polishing resistance of the specific aggregate present on the surface.
The variation in density is dependent on the specific aggregate in question.
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In order to determine whether SGD aggregation could be under the control of one or more specific aggregating factors in C. roseus, we studied the localisation of CrSGD in onion epidermis, a remote non MIA-producing plant model.
(a) Fluorescence images of chains formed by application of DEP to a suspension containing equal numbers of 2.2 μm positive (green) and 2.0 μm negative (red) latex particles; insets show specific aggregates at higher magnification (structures equivalent to B2 in Fig. 1b).
To asses the alignment order of specific aggregates, we use the nematic order parameter P2, which discriminates between uniaxial, ordered or disordered (amorphous) conformations (see Methods).
If it is the general case that specific aggregate-prone proteins can disrupt the proteostasis of the entire cell [ 40], then the circadian clock, via its widespread influence upon the proteome [ 24 ], may well be able to aggravate or attenuate aggregation-induced autophagy and susceptibility to mitochondrial dysfunction and cellular apoptosis.
The specific aggregates of fibroblasts, myofibroblasts, and extracellular matrix (ECM) proteins in fibrotic lung are called fibroblast foci (FF), and these structures are more common in IPF than in other types of lung fibroses.
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