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ALS-causing SOD1 mutations apparently alter this pathway by increasing exposure of buried epitopes in misfolded species populated at endpoint.
A tertiary, T-state, neamine species populated at ∼3% was also detected by NMR at pD 7.4.
Monomeric forms of YibK display similar characteristics to an intermediate species populated during the formation of the wild-type dimer.
Identification and characterization of various cytotoxic species populated during the complicated aggregation process would be of great importance in developing therapeutic strategies for the protein misfolding disorders.
To characterize fully the unfolding landscape, however, it is necessary both to explore the entire force spectrum and to characterize each species populated during unfolding.
In this report, we isolated small oligomeric species populated during TTR oligomerization process and investigated structural features of the cytotoxic oligomeric species of WT and a mutant form of TTR (G53A).
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Isomers of this family are among the list of chemical species populating the interstellar medium.
In summary, the body of data reported here describes the architectures of three EGFR non-monomer ligand-free species populating the cellular basal state (Fig. 8).
The performers move about on a mostly bare stage, suggesting, without being too definite, organisms of various species populating the earth and a human contingent exploring, settling, mastering, and running amok.
The biogeography of flightless birds, finches, and fossils suggested that species populating those landscapes, as well as the underlying strata, likewise evolved.
It is unlikely that birch is less well adapted to the dry and sometimes hot steppe conditions as this species populates the most southern outposts of all tree species of the Northern Mongolian steppe forests (Otoda et al. 2013; Gradel et al. 2017), notably in areas where larch have trouble surviving.
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