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It is now recognized that there are two major specialized zones of cell proliferation in the adult brain: the subventricular zone (SVZ) and the dentate gyrus.
Based on these observations, it is proposed that intersectin-1 can act as a scaffolding protein that targets and holds proteins of the endocytic machinery at specialized zones of the plasma membrane.
Within the cytoplasm, myosins are localized to various specialized zones, viz.
NoRs are highly specialized zones in myelinated axons containing high densities of voltage-gated sodium channels (Navs) and associated cytoskeletal complexes, creating active zones essential for saltatory conduction of action potentials (APs) (Debanne et al., 2011).
We observed immunolocalization of endogenous VGLUT proteins in both primary MKs and MEG-01 cells, as well as localization of EGFP-tagged VGLUT1 in MEG-01 cells prominently at the plasma membrane consistent with vesicular release activity identified in peripheral specialized zones in neuronal cells [27].
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Clathrin-coated pits near PSDs have been proposed to be specialized endocytic zones (EZs) (Blanpied et al., 2002; Racz et al., 2004) that mediate endocytosis of AMPA receptors for local recycling in spines (Lu et al., 2007; Petrini et al., 2009; Kennedy et al., 2010).
Hence, dopamine secretion is mediated by sparse, mechanistically specialized active zone-like release sites.
These co-ordinates correspond to the lateral occipital complex (LOC), a large cortical zone specialized for shape and object perception and in which several subdivisions have been recognized [5], [6].
Basally branching lineages occupy transitional zones and can walk both on water and land, while derived lineages have specialized in open-water zones and propel their body by means of surface rowing (Gerris, Limnoporus, Rhagovelia and Metrobates) [ 40, 41].
Protein sets representing each zone was then subjected to a pathway over-representation analysis in order to determine whether the zones were specialized for specific functions.
The Miracle specialized in a matchup zone defense that the Liberty has only occasionally seen.
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