Thus genes with a more specialised function (lower overall expression and higher degree of tissue specificity) seem to be evolving at a higher rate (or with less constraint) than genes with a more general function (high overall expression and low degree of tissue specificity).
In mammalian, eEF1A1 is ubiquitously expressed, whereas eEF1A2 expression is switched-on in adult life in specialised tissues such as skeletal muscle, cardio-myocytes and nervous system (Knudsen et al, 1993).
Cops-1 shows a strong bias in codon preference necessitating specialised strains of E. coli for expression of recombinant protein.
The expressed VSG is located in specialised subtelomeric transcription units known as the Bloodstream Expression Sites (BES).
Typically, secreted mucins are expressed exclusively by specialised epithelial cells, are secreted in the mucus, and display a restricted expression pattern within the human body.
Immunohistochemical studies will be required to fully identify the specialised cells involved in the increased MT expression.
We do not consider the selection of patients in our study a methodological weakness, but rather an expression of clinical reality in specialised care.
However, studies demonstrating the activity of RelE in eukaryotic cells are currently limited to artificial expression of the toxin using a specialised vector [ 51, 52].
Strong Bcl-G expression was also observed in the more specialised acinar epithelial cells within exocrine tissues, such as the salivary and lacrimal glands.
The expression of EEF1A2 in tissues other than specialised tissues has been associated to cancer development and aggressiveness, playing a role in ovarian, breast, lung, gastric, hepatic (Lee and Surh, 2009) and pancreatic (Cao et al, 2009) cancers.
