The molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and β-catenin.
These data are consistent with sensorin expression being spatially regulated at the level of translational regulation rather than mRNA targeting.
This suggests that Notch signalling in the heart is spatially regulated by Robo expression, with maximum regulation when both Robo1 and Robo2 are present.
These data demonstrate that non-TRs can activate some TREs in a spatially regulated manner, whereas other TREs respond only to the known TRs, which also read out activity in a spatially regulated manner.
Coupled with spatially regulated translation of mRNA, these processes are an important mechanism of post-transcriptional regulation of gene expression throughout eukaryotic life [3].
In intact Hydra polyps, the expression of neurogenesis genes is spatially regulated, being restricted to the i-cells in the central portion of the body, and that of neurotransmitter genes is highest at the head and foot regions, where the nervous system is densest.
The expression of two ASNase genes was temporally and spatially regulated.
Do TPR GoLoco proteins function as conserved, spatially regulated mediators of spindle orientation by intercellular signaling?
MicroRNAs are temporally expressed during neural differentiation, spatially regulated and embedded in molecular feedback loops that may contribute to the robustness of the neural networks.
How these functions of RACK1A are regulated or how its interactions with other proteins are temporally and spatially regulated after pathogen infection remain to be studied in the future.
This suggests AES activity is also spatially regulated in HEK 293T cells.
