Sentence examples for spatial uncoupling of from inspiring English sources

The spatial uncoupling of β-catenin phosphorylated at T41/45 from that phosphorylated at S33/37/T41 is particularly interesting, because it suggests that phosphorylation at S45 serves a function beyond simply priming β-catenin for subsequent phosphorylations by GSK3.

Thus, the analysis of DGR structures has uncovered two mechanistic aspects of DGR-mediated mutagenesis: transcriptional separation of RT and TR expression, and spatial uncoupling of DGR expression and VR targeting.

It is tempting to speculate that rapid spatial uncoupling of TRPC3 from NCX will lower local Na+ at the exchanger during repolarization, which is expected to impact differentially on reverse and forward-mode operation of NCX, promoting preferentially forward-mode Na+ entry.

Excessive activation of TRPC3 is associated with transient cellular Ca2+ overload, spatial uncoupling between TRPC3 and NCX1, and arrhythmogenesis.

Compared with the high degree of overlap during the intermediate stages of ictal evolution, ictal termination was exemplified by an uncoupling of CBV and membrane potential and little spatial overlap (Fig. 9).

This analysis showed that the coupling and uncoupling of horizontal cells does not play a dominant role in spatial tuning and its adjustability to night and day light conditions.

The results showed that the coupling and uncoupling of horizontal cells does not play a critical role in spatial tuning, that is, it does not substantially contribute to the mechanism that controls the changes in spatial tuning that occur with the switch from night to day vision.

In sum, with the aid of a Connexin57 knock out, we were able to test the long-standing hypothesis that the coupling and uncoupling of horizontal cells serves as a critical knob for adjusting spatial tuning to different light conditions, i.e., to night versus day conditions.

Ganglion cells from Cx57-deficient mice showed essentially the same behavior (no statistically significant difference), providing further evidence that the coupling and uncoupling of horizontal cells is not the critical mechanism that underlies the change in spatial tuning that occurs with different light intensities.

This model is revealing heightened production of reactive oxygen species that result from uncoupling of eNOS.

Here we show that PCNA ubiquitination also requires uncoupling of helicase and polymerase activities.