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Pre-processing of functional scans consisted of corrections for head motion (spatial realignment; trilinear interpolation) and scans were realigned to the first volume of the last functional scan (i.e., the volume closest to the anatomical scan).
Because GGBP undergoes a large conformational change on the addition of glucose, rational placement of these sites allowed glucose-dependent spatial realignment of the two fluorophores, which was monitored as a change in fluorescence intensity and extinction coefficients.
Two primary mechanisms of adaptation have been (generally) agreed upon: spatial realignment and strategic control [4].
Images were pre-processed using SPM5 (http://www.fil.ion.ucl.ac.uk/spm/), employing spatial realignment and sequential co-registration (6 parameter rigid body spatial transformation).
In contrast, spatial realignment is a result of the registered difference between the performance expected from a feed-forward movement plan and the performance achieved under feedback control, signalling a discrepancy between spatial maps.
It is important to note that strategic control processes are a form of adaptation often observed in the prism literature, and it is thought to play a pivotal role in initiating spatial realignment [4].
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The 2002 version of Statistical Parametric Mapping (SPM2: software from the Wellcome Department of Cognitive Neurology, London, UK) was used for spatial transformations (realignment, transformation into standard stereotactic space, and smoothing with an isotropic Gaussian kernel of 8 mm FWHM), and statistical analysis [ 31].
The preprocessing included realignment, spatial normalization, and spatial smoothing (8 mm).
Pre-processing of the functional MRI data (using SPM5 software, Wellcome Institute of Imaging Neuroscience, London, UK) comprised realignment, spatial normalization and spatial smoothing.
Preprocessing of the functional MRI data (using SPM5 software, Wellcome Department of Imaging Neuroscience, London, UK) comprised within-subject realignment, spatial normalization and spatial smoothing.
Preprocessing included realignment, spatial normaliziation to the EPI-template (2×2×2 mm) and spatial smoothing (8 mm).
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