The spatial outlier loci on LG7 were correlated with longitude, which is expected given that these loci seemed divergent only between the Iceland-inshore cluster and the rest.
Plot of the Bayesian Information Criterion (BIC) for clustering solutions with different numbers of clusters (K) based on all loci (A) and a subset of loci (n = 618) excluding temporal and spatial outliers and loci in high LD (B). Figure S4.
Plots to illustrate the configuration of inferred clustering solutions for K = 2 4 based on all loci (A) and a subset of loci (n = 618) excluding temporal and spatial outliers and loci in high LD (B). Figure S5.
High resolution CT studies (GE Healtcare eXplore Locus; spatial resolution, 45 µm) were performed within 24 h from the PET.
Furthermore, brain imaging studies have shown that the time course and neural locus of spatial working memory and spatial attention are so similar that spatial working memory may be best characterized as a form of retrospective spatial attention.
Chromatin remodeling associated to DNA synthesis, CTs relative positioning, loci spatial proximity, intermingling of chromatin loops and transcriptional activity could be critical to determine chromosome damage localisation, genomic instability and cancer-prone translocation frequencies.
In this Select, we present two cases in which a specific histone modification causes changes to the local chromatin architecture, in turn impacting nearby gene regulation, and an example of how the spatial organization of loci creates an environment that leads to coregulation of distant genes.
The first, established from pairs of translocated genes (such as BCR and ABL), considers the spatial proximity of loci in interphase nuclei (static "contact first" model).
These observations have established a direct correlation between the spatial proximity of loci in interphase nuclei and the frequency of their translocation.
These 3 features are therefore all related to the conservation of the spatial arrangement of loci, but it remains an open question which of these features, if any, is the driver.
