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Therefore, these large 3-D scaffolds become a spatial hindrance for bone regeneration.
This neglects an effect of spatial hindrance of the electrophilic substitution reaction within micropores.
Obviously, polymerization results in much larger spatial hindrance of long PANI molecules when forming crystalline composite structures based on hexagonal GaSe.
Each dendrimer presented a particular behavior concerning to the following investigated properties: spatial hindrance, map of electrostatic potential (MEP), and the lowest unoccupied molecular orbital energy (ELUMO).
However, the relatively large size of the dextran molecule in aqueous phase appears to create spatial hindrance compromising the penetrative ability of the detection reagent.
Large spatial hindrance amino groups were selected for the basic modification step to avoid spontaneous recombination and neutralization reactions between the two antagonist functional groups.
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The spatial steric hindrance of the methyl groups at 1- and 7- positions prevented intramolecular displacement of sulfur with amino group of Hcy but not of Cys.
The possibility of any side-product formation with amine groups present on the bases is negligible as the coupling reaction is thermodynamically/kinetically unfavorable due to excessive steric hindrance (spatial crowding).
However, steric hindrance and spatial configuration of the grafted chains had substantially limited the extent of protonation of the EM substrate by the protonic acid functional groups of these chains.
Hydrophobicity, the presence/absence of some functional groups, steric hindrance and spatial arrangement all play important roles in the affinity of natural polyphenols towards plasmatic proteins [13].
This is consistent with the hypothesis of statistical spatial distribution limited by steric hindrance resulting from mAb size (MW≈180 000).
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